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Dapoxetine Tablets

Dapoxetine Tablets

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Tadalafil Dapoxetine tablet is an appropriate medicine for men suffering from impotence due to Erectile Dysfunctions (ED) and Premature Ejaculation (PE). Tadalafil is a PDE 5 inhibitor meant to treat ED and Dapoxetine is a selective serotonin inhibitor which is used for PE. Combination therapy is found to be more efficacious than any of the individual drug. 

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It is combination drug therapy in which both active ingredients- Tadalafil and Dapoxetine act synergistically to treat male impotence. It is employed for treatment of men suffering from both erectile dysfunction (ED) and premature ejaculation (PE). Tadalafil is a potent oral Phosphodiesterase 5 (PDE5) inhibitor which acts in a similar way to popular Viagra (sildenafil). Dapoxetine is a selective serotonin reuptake inhibitor. This medicine is one of the efficacious medicines in patients suffering from both ED and PE.

Erectile Dysfunction is characterised by failure to achieve and maintain penile an erect penis during intercourse. Patient is unable to maintain the hardness and stiffness of penis required for successful intercourse.

Premature ejaculation (PE) is a condition in which the patient ejaculates immediately after sexual stimulation sometimes even before insertion. This is a very frustrating condition and patient can not feel the orgasmic pleasure.  

How does it work?

Tadalafil: Erection of penis is physiological process which results due to pooling of blood in penile blood vessels. During sexual stimulation, nitric oxide is produced by nerve endings which stimulate some chemicals like cyclic guanosine monophosphate (cGMP) to get release. cGMP bring out the smooth muscle relaxation of penile blood vessels. Tadalafil inhibits cyclic-GMP–specific Phosphodiesterase type 5 (PDE5), which carry out the degradation of cGMP. Inhibition of PDE5, enhance cGMP concentration and thus activity which results in a success erection.

Dapoxetine: serotonin is a neurotransmitter which commands ejaculatory reflex. Dapoxetine hinders the reuptake of serotonin from the nerve endings by 5-HT transporters, and promote serotonin action. This lengthens the duration of ejaculation.

What are the contraindications?

  1. This medicine is contraindicated in patients having allergy to tadalafil and/or Dapoxetine.

  2. This medicine is prohibited in women and under 18 males.

  3. Nitrates (like nitroglycerin) or recreational drugs (poppers) like amyl nitrate and butyl nitrate should not be used with this medicine.

  4. A dose fixation is required in patient with hepatic and/or renal insufficiency.  

What are the warnings/precautions?

  1. Make an avoidance to consume diet rich in fat while using this medicine. It augments the side effects.

  2. Minimize the use of alcohol with this medicine because it can diminish alertness severely.

  3. This medicine can lead to dizziness and blurring of vision; so do not perform activities which require alertness or clear sight after consuming the medicament.

  4. In patients with a history of heart attack, blood related disorders, renal insufficiency, prostate disorders, and mental disease should tell the doctor before using this medicine.

  5. This medicine does not safeguard against sexually transmitted diseases; so use a protective measure during intercourse.

What are the side-effects?

The side effects are: Back and muscle pain, lowering of blood pressure, sudden loss of vision or/and hearing,  dizziness, flushing, nausea, irregularity in heart beats, abdominal pain, drowsiness, painful erection lasting for more than 4 hours ( this side effect occurs rarely but requires emergency medical treatment).

What are the possible drug interactions?

This medicine shows interaction with the below mentioned medicines:

  1. Alpha blocker like prazocin, doxazocin, terazocin

  2. Anti-angina drugs like nitrate and nitrite containing medicines.

  3. Anti-fungal drugs like fluconazole, voriconazole

  4. Other PDE5 inhibitors like Avanafil,sildenafil, verdenafil

  5. Other selective serotonin reuptake inhibitors

  6.  CYP3A4 inhibitors like ritonavir, rifampin, phenytoin, phenobarbital, carbamazepine

What should be done in case of missed dose?

This medicine is meant to be used on requirement basis, so the case of missed dose does not exist

What should be done in case of overdosing?

 In case of overdosing immediately go to emergency centre.

What is the Dosage and how this medicine should be taken?

Always follow the dosage regimen prescribed by physician; never enhance the dose for getting more benefits. This medicine should be taken orally once daily 1 to 2 hours prior to lovemaking. Take the tablet with water and avoid fat containing food with it.

What should be the Storage conditions?                                                                           

The medicine should be placed in cool and dry place at 15 to 30 degree Celsius.  Do not expose the medicine to severely hot or cold temperature. Keep out of the reach of children and pets. The medicine should not be stored in bathroom or any other humid place.

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